Drug products

Orally Disintegrating Tablet Technology (Patented) with Multi-Layer Tableting Technology

We have the technology to manufacture orally disintegrating tablet with "high tablet hardness / very fast disintegration / low cost." At the same time, it is possible to combine with multi-layer tableting technology used for avoiding drug-drug interaction and for developing combination drugs. We can also manufacture small size (6mm diameter) three-layer tablet which results in improving acceptability.

External Lubrication Tableting Technology (Patented)

External lubrication tableting technology is to compress the tableting powder/granules after coating the punch and die with lubricant. This greatly reduces the lubricant content in the tablet. This technology reduces the mutual interaction between lubricant and API and then, improves stability of API while reducing disintegration time and increasing hardness. Additionally, this technology can reduce issues that may occur during tablet compression, such as sticking. One stop service is possible from the early stage of formulation development to commercial manufacturing, since we have equipment for laboratory, clinical and commercial use. It is possible to combine with the orally disintegrating tablet technology and with multi-layer tableting technology.

Suspension Technology (patented)

This suspension technology used for dry syrup has superb water suspension characteristics compared to other companies' technologies, making it superior in drug usability. Also, this technology is superior in term of defoaming property (foam breaking) after shaking, making it easier for patients' acceptability.

Usage Example for Pediatric Fine Granules

For pediatric fine granules, we have wax matrix technology to mask drug bitterness. When this technology was used for fine granules, the granules suspended in water floats on the surface and it was difficult to be administrated. However, applying our new suspension technology, we are able to create uniform suspension without loss of masking function. This patented technology will greatly improve acceptability.

Absorption Enhancement Technology for Poorly Soluble Drugs

We have the manufacturing technology of solid dispersion using spray dry technology and nano particle technology for enhancing the absorption of poorly soluble drugs.
The figure below shows the plasma drug concentration after administering conventional formulation and formulation with our technology.

Manufacturing Technology of Solid Dispersion Using Spray Dry Technology

Since we have various scale facilities that can handle organic solvents, it is possible to proceed as a one stop service from the early stage of formulation development to commercial production.

Nano-particle Technology

We are developing a unique technology to greatly reduce elemental impurities.

Fine Particle Coating Technology

Using fine particle coating technology, it is possible to control drug release and drug absorption site. Shionogi Pharma has a multi-layer fine particle coating technology with uniform thickness. This stabilizes drug release via dissolution control layer. In addition, we have manufacturing technology that reduces the adhesion of fine particles to each other during coating, which enables high yields.

High Potent DDS-based Injectables

Next Generation Lyophilization Technology

There are three processes in the normal lyophilization process.

(1)Freezing process
(2)First drying process
(3)Second drying process
In conventional technology, super cooling before freezing in the lyophilization process results in formation of small ice crystals and ice crystal is difficult to be sublimed during the first drying process, which may cause increase in drying time. On the other hand, with the next generation lyophilization technology, ice fog is blown in during the freezing process to become crystal nuclei and as a result, ice crystal size is larger and ice crystal is easier to be sublimed during the first drying process. This greatly reduces the drying time and improves productivity.